MicroRNA-181c inhibits glioblastoma cell invasion, migration and mesenchymal transition by targeting TGF-β pathway

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• 作者：Xin He ; Zengjin Liu ; Yutao Peng ; Chunjiang Yu ; ^{chunjiangyu1955@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Glioblastoma ; MicroRNA-181c ; EMT ; TGF-β
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2016
• 出版时间：22 January 2016
• 年：2016
• 卷：469
• 期：4
• 页码：1041-1048
• 全文大小：2468 K

文摘

MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignancies. In this study, we found that miR-181c was down-regulated both in glioblastoma tissues and cell lines. We also annotated 566 TCGA miRNA expression profiles and found that patients with high microRNA-181c (miR-181c)-expressing tumors had significantly longer OS and PFS. Overexpression of miR-181c evidently inhibited glioblastoma cell line T98G migration and invasion. Further, the expression of E-cadherin was significantly upregulated and that of N-cadherin and vimentin was significantly down-regulated. We also found that miR-181c overexpression inhibited TGF-β signaling by down-regulating TGFBR1, TGFBR2 and TGFBRAP1 expression. Overall, our study found that miR-181c plays a key role in glioblastoma cell invasion, migration and mesenchymal transition suggesting potential therapeutic applications.