Functions of MDA5 and its domains in response to GCRV or bacterial PAMPs
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- 作者：Tianle Gua ; Youliang Raoa ; Jianguo Sua ; b ; c ; sujianguo2015@163.com" class="auth_mail" title="E-mail the corresponding author ; Chunrong Yanga ; Xiaohui Chena ; Lijun Chena ; Nana Yana
- 关键词：Grass carp (Ctenopharyngodon idella) ; MDA5 ; RLR pathway ; GCRV ; CIK cells
- 刊名：Fish & Shellfish Immunology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：46
- 期：2
- 页码：693-702
- 全文大小：2142 K
文摘
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CiMDA5 could respond to GCRV, poly(I:C), LPS and PGN stimulation.
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CARD domain alone could induce signaling cascade after GCRV or bacterial PAMPs stimulation.
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Helicase or RD domain alone negatively regulates CARD domain function by intramolecular interaction.
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RD domain enhances the function of CARD domain by intermolecular interaction.