Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats

详细信息    查看全文

• 作者：Naomi Lomeli^a ; ^{nrlomeli@uci.edu} ; Kaijun Di^b ; ^c ; ^kdi@uci.edu ; Jennifer Czerniawski^d ; ^e ; ^{jczernia@uci.edu} ; John F. Guzowski^d ; ^e ; ^{john.g@uci.edu} ; Daniela A. Bota^a ; ^b ; ^c ; ^f ; ^{dbota@uci.edu}
• 关键词：CDDP ; cisplatin ; COD ; context object discrimination ; FC ; fear conditioning ; NAC ; N-acetylcysteine ; NOR ; novel object recognition ; NSCs ; neural/stem progenitor cells ; ROS ; reactive oxygen species ; TUNEL ; terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：274-286
• 全文大小：1663 K
• 卷排序：102

文摘

Cisplatin induces cognitive impairments. Cisplatin reduces hippocampal dendritic branching and spine density. Cisplatin causes neural mitochondrial dysfunction and apoptosis. NAC reduces cisplatin-induced cognitive impairments. NAC ameliorates cisplatin-mediated mitochondrial damage by reducing oxidative stress.