Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3
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- 作者：Margaret Lois Thomasa ; Roberto de Antuenob ; Krysta Mila Coylea ; Mohammad Sultana ; Brianne Marie Cruickshanka ; Michael Anthony Giacomantonioa ; Carman Anthony Giacomantonioa ; c ; Roy Duncanb ; Paola Marcatoa ; b ; paola.marcato@dal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; ALDH1A3 ; Aldefluor ; Cancer stem cell
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：10
- 期：9
- 页码：1485-1496
- 全文大小：3802 K
文摘
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Citral is a specific inhibitor of cancer stem cell marker ALDH1A3.
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Aldefluor fluorescence of breast tumor cells is blocked by citral.
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Citral inhibits ALDH1A3-driven breast tumor growth in vivo.
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ALDH1A3-mediated colony formation and gene expression is inhibited by citral.
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