Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity
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- 作者：Jennifer E. Cropley1 ; 2 ; 8 ; j.cropley@victorchang.edu.au" class="auth_mail" title="E-mail the corresponding author ; Sally A. Eaton1 ; 2 ; 8 ; Alastair Aiken1 ; Paul E. Young1 ; Eleni Giannoulatou1 ; Joshua W.K. Ho1 ; 2 ; Michael E. Buckland3 ; Simon P. Keam4 ; Gyorgy Hutvagner4 ; David T. Humphreys1 ; Katherine G. Langley5 ; Darren C. Henstridge5 ; David I.K. Martin1 ; 6 ; Mark A. Febbraio7 ; Catherine M. Suter1 ; 2 ; c.suter@victorchang.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Paternal effects ; Epigenetic inheritance ; Noncoding RNA ; Sperm RNA
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：5
- 期：8
- 页码：699-708
- 全文大小：1204 K
文摘
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Paternal obesity induces latent defects in metabolism in F1 sons.
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Metabolic disease in F1 sons is exposed by short challenge with a Western diet.
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F1 sons transmit their phenotype to F2 grandsons in the absence of dietary challenge.
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F1 sperm exhibit changes to prominent small RNA species.