Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study

详细信息    查看全文

• 作者：Enrico De Vita^a ; ^b ; ^{e.devita@ucl.ac.uk} ; Gerard R Ridgway^c ; ^d ; ^{g.ridgway.01@cantab.net} ; Mark J White^a ; ^b ; ^{mark.white@ucl.ac.uk} ; Marie-Claire Porter^e ; ^f ; ^{marie-claire.porter.10@ucl.ac.uk} ; Diana Caine^e ; ^f ; ^{Diana.Caine@uclh.nhs.uk} ; Peter Rudge^e ; ^f ; ^{peter.rudge@prion.ucl.ac.uk} ; John Collinge^e ; ^f ; ^{john.collinge@prion.ucl.ac.uk} ; Tarek A Yousry^a ; ^b ; ^{t.yousry@ucl.ac.uk} ; Hans Rolf Jager^a ; ^b ; ^{r.jager@ucl.ac.uk} ; Simon Mead^e ; ^f ; ^{s.mead@prion.ucl.ac.uk} ; John S Thornton^a ; ^b ; ^{john.thornton@ucl.ac.uk} ; Harpreet Hyare^e ; ^f ; ^{harpreet.hyare@nhs.net}
• 关键词：Prion disease ; Structural MRI ; Longitudinal voxel based morphometry ; 3T MRI ; CJD
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：89-96
• 全文大小：696 K
• 卷排序：13

文摘

Longitudinal brain structural 3T MRI voxel based morphometry in 24 prion disease patients In several regions volume loss correlated with increased disease severity as evidenced by decreased prion MRC Scale score Prion patients' yearly rates of volume loss are significantly greater than those of healthy controls