Polymyxin B immobilized on cross-linked cellulose microspheres for endotoxin adsorption
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- 作者：Xiaodong Caoa ; b ; Biyan Zhua ; b ; Xufeng Zhangc ; Hua Donga ; donghua@scut.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cellulose microspheres ; Inverse crosslinking suspension ; PMB ; Blood purification ; Endotoxin
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：12-18
- 全文大小：1773 K
文摘
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Cross-linked cellulose microspheres were successfully prepared.
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Polymyxin B was immobilized on CL-CMs to synthesize endotoxin adsorbent.
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Adsorption capacity of endotoxin in physiologic saline solution was 3600 EU/g.
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Adsorption efficiency of endotoxin in human plasma was more than 70%.
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Adsorbents showed low nonspecific adsorption of 8.9% for human plasma protein.