Opposing roles of IL-10 in acute bacterial infection

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• 作者：Herná ; n F. Peñ ; aloza^aAuthor Vitae ; Barbara M. Schultz^aAuthor Vitae ; Pamela A. Nieto^aAuthor Vitae ; Geraldyne A. Salazar^aAuthor Vitae ; Isidora Suazo^aAuthor Vitae ; Pablo A. Gonzalez^aAuthor Vitae ; Claudia A. Riedel^bAuthor Vitae ; Manuel M. Alvarez-Lobos^cAuthor Vitae ; Alexis M. Kalergis^a ; ^d ; ^eAuthor Vitae ; Susan M. Bueno^a ; ^e ; ^{sbueno@bio.puc.cl}Author Vitae
• 关键词：Interleukin-10 ; Acute bacterial infection ; Innate immunity ; Extracellular bacteria ; Intracellular bacteria ; Inflammation severity
• 刊名：Cytokine & Growth Factor Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：Complete
• 页码：17-30
• 全文大小：1857 K
• 卷排序：32

文摘

IL-10 production is regulated by epigenetic, transcription factors and post-transcriptional mechanisms, ensuring a balanced production during bacterial infections. During infections with extracellular or highly inflammatory bacterial pathogens, IL-10 production facilitates host survival. During infections with intracellular or low inflammatory bacterial pathogens, IL-10 production facilitates bacterial dissemination, increasing death rate. Predicting the effect of the presence/absence of IL-10 during bacterial infections could improve treatment efficacy as well as facilitates the development of new drugs and therapies.