Application of a novel liquid chromatography/tandem mass spectrometry method for the determination of antazoline in human plasma: Result of ELEPHANT-I [ELEctrophysiological, pharmacokinetic and hemodynamic effects of PHenazolinum (ANTazoline mesylate)] hu
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- 作者：Joanna Giebułtowicza ; joanna.giebultowicz@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Roman Piotrowskib ; Jakub Baranb ; Piotr Kułakowskib ; Piotr Wroczyńskia
- 关键词：AF ; atrial fibrillation ; AN-PAF ; Clinical efficacy of ANtazoline in rapid cardioversion of Paroxysmal Atrial Fibrillation ; a single center ; randomized ; double blind ; placebo-controlled study ; AUCt ; area under the plasma concentration-time curve from time zero to time t ; AUC&infin ; area under the plasma concentration-time curve from time zero to infinity ; C0 ; back-extrapolated plasma drug concentration at time zero following bolus intravenous injection ; Cl ; apparent total body clearance of the d
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：113-119
- 全文大小：784 K
文摘
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First LC–MS/MS method for determination of antazoline in human plasma.
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Application of the method to pharmacokinetic characteristic of antazoline in human.
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The prelude to further study on the optimal dosing of antazoline in paroxysmal atrial fibrillation.