Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities
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- 作者：Rungrot Cherdtrakulkiata ; Somchai Boonpangrakb ; Nujarin Sinthupooma ; Supaluk Prachayasittikulc ; supaluk@swu.ac.th" class="auth_mail" title="E-mail the corresponding author ; Somsak Ruchirawatd ; e ; Virapong Prachayasittikula ; virapong.pra@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：8-Hydroxyquinoline ; Nitroxoline ; Clioquinol ; Cloxyquin ; Antimicrobial ; Antioxidant
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：6
- 期：Complete
- 页码：135-141
- 全文大小：366 K
文摘
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8-Hydroxyquinoline exerted highly potent antibacterial activity (Gram positive).
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Nitroxoline exhibited strong antibacterial activity against Pseudomonas aeruginosa.
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Cloxyquin displayed a high growth inhibition against Listeria monocytogenes and Plesiomonas shigelloides.
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5-Amino-8-hydroxyquinoline exerted the most potent antioxidant activity (IC50=8.70 μM).
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Nitroxoline and cloxyquin had a relatively high selectivity index.