Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum

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• 作者：Cristina D'Aniello¹ ; Ehsan Habibi² ; Federica Cermola¹ ; Debora Paris³ ; Francesco Russo⁴ ; Alessandro Fiorenzano¹ ; Gabriele Di Napoli¹ ; Dominique J. Melck³ ; Gilda Cobellis⁵ ; Claudia Angelini⁴ ; Annalisa Fico¹ ; Robert Blelloch⁶ ; Andrea Motta³ ; Hendrik G. Stunnenberg² ; Dario De Cesare¹ ; ^{dario.decesare@igb.cnr.it} ; Eduardo J. Patriarca¹ ; Gabriella Minchiotti¹ ; ^{gabriella.minchiotti@igb.cnr.it}
• 关键词：vitamin C ; l-proline ; DNA methylation ; naive pluripotency ; early primed pluripotency ; metabolic reprogramming ; metabolomics
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：1-10
• 全文大小：2554 K
• 卷排序：8

文摘

Global DNA methylation is modulated by l-Pro and VitC availability in ESCs l-Pro and VitC relative levels induce naive and reversible primed pluripotency High l-Pro/low VitC levels induce metabolic reprogramming in ESCs l-Pro induces and sustains autocrine FGF and TGF-β signaling in ESCs