Discrepancy between electroencephalography and hemodynamics in a patient with Cockayne syndrome during general anesthesia

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• 作者：Masanori Tsukamoto ; DDS ; PhD^a ; ^{tsukamoto@dent.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} (Assistant Professor) ; Takashi Hitosugi ; DDS ; PhD^b ; ^{hitosugi@dent.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} (Assistant Professor) ; Takeshi Yokoyama ; DDS ; PhD^b ; ^{yokoyama@dent.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} (Professor)
• 关键词：Cokayne syndrome ; General anesthesia ; Electroencephalograhpy
• 刊名：Journal of Clinical Anesthesia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：35
• 期：Complete
• 页码：424-426
• 全文大小：217 K

文摘

Cockayne syndrome is a kind of progeria with autosomal chromosome recessiveness described first by Cockayne in 1936. Patients with this syndrome were characterized by retarded growth, cerebral atrophy, and mental retardation. We experienced an anesthetic management of a patient with Cockayne syndrome, who underwent dental treatment twice. The primary concern was discrepancy between electroencephalography and hemodynamics. The values of bispectral index showed a sharp fall to 1 digit and suppression ratio more than 40, while hemodynamics was stable during induction of anesthesia with sevoflurane 8%. We should pay attention to anesthetic depth in the central nervous system in patients with Cockayne syndrome. Titration of anesthetics should be performed by the information from electroencephalography.