Roles of acetyl-CoA synthetase (ADP-forming) and acetate kinase (PPi-forming) in ATP and PPi supply in Entamoeba histolytica
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- 作者：Erika Pinedaa ; 1 ; Citlali Vá ; zqueza ; 1 ; Rusely Encaladaa ; Tomoyoshi Nozakib ; Emi Satob ; Yuki Hanadateb ; Mario Né ; quizc ; Alfonso Olivos-Garcí ; ac ; Rafael Moreno-Sá ; ncheza ; Emma Saavedraa ; emma_saavedra2002@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acetyl-CoA ; acetyl-coenzyme A ; ACS ; acetyl-CoA synthetase (ADP forming) ; AcK ; acetate kinase (PPi-forming) ; Acetyl-P ; acetyl phosphate ; ADHE ; bifunctional aldehyde-alcohol dehydrogenase ; ALDO ; fructose-1 ; 6-bisphosphate aldolase ; CoA ; coenzyme A ; ENO ; enolase ; Fru6P ; fructose-6-phosphate ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; Glc6P ; glucose-6-phosphate ; HK ; hexokinase ; HPI ; hexosephosphate isomerase ; PFOR ; pyruvate ; ferredoxin oxidoreductase ; PGAM ; 3-phosphoglycerate mutase ; PGK ; 3-phos
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1163-1172
- 全文大小：789 K
文摘
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Enzymes involved in acetate production in Entamoeba histolytica were studied.
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In axenic amoebae acetate is produced only by acetyl-CoA synthetase (ACS).
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ACS does not significantly contribute to ATP production in the parasite.
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ACS is responsible for CoA regeneration under oxidative stress conditions.
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PPi-acetate kinase appears to have a marginal contribution to PPi supply.
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