Structure and anticoagulant property of a sulfated polysaccharide isolated from the green seaweed Monostroma angicava

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• 作者：Na Li^a ; ^b ; Xue Liu^a ; Xiaoxi He^a ; Shuyao Wang^a ; Sujian Cao^a ; Zheng Xia^a ; Huali Xian^a ; Ling Qin^a ; Wenjun Mao^a ; ^c ; ^{wenjunmqd@hotmail.com}
• 关键词：Acetonitrile (PubChem CID ; 6342) ; Barium rhodizonic acid (PubChem CID ; 45048930) ; Dimethyl sulfoxide (PubChem CID ; 679) ; d-Glucuronic acid (PubChem CID ; 94715) ; Heparin (PubChem CID ; 25244225) ; Iodomethane (PubChem CID ; 6328) ; l-Phenyl-3-methyl-5-pyrazolone (PubChem CID ; 90474051) ; Pullunan (PubChem CID ; 92024139) ; Pyridine (PubChem CID ; 1049) ; Rhamnose (PubChem CID ; 25310)
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：159
• 期：Complete
• 页码：195-206
• 全文大小：3403 K
• 卷排序：159

文摘

Sulfated polysaccharide PF2 was isolated from the green seaweed Monostroma angicava. PF2 is a rhamnan-type sulfated polysaccharide with specific rhamnopyranose units. PF2 possesses a high anticoagulant activity in vitro. PF2 is a strong thrombin inhibitor mediated by heparin cofactor II. PF2 could be a potential anticoagulant polysaccharide.