Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints

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• 作者：Andrew J. Holmes¹ ; ² ; ⁷ ; ^{andrew.holmes@sydney.edu.au} ; Yi Vee Chew² ; Feyza Colakoglu² ; John B. Cliff³ ; Eline Klaassens¹ ; ² ; Mark N. Read¹ ; ² ; Samantha M. Solon-Biet¹ ; ² ; ⁴ ; ⁵ ; Aisling C. McMahon¹ ; ⁴ ; ⁵ ; Victoria C. Cogger¹ ; ⁴ ; ⁵ ; Kari Ruohonen⁶ ; David Raubenheimer¹ ; ² ; David G. Le Couteur¹ ; ⁴ ; ⁵ ; Stephen J. Simpson¹ ; ² ; ^{stephen.simpson@sydney.edu.au}
• 关键词：gut microbiome ; nutritional geometry ; aging ; geometric framework ; mucin ; microbial ecology ; obesity ; diet
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：140-151
• 全文大小：3749 K
• 卷排序：25

文摘

Gut microbes show a dichotomy in ecological strategy for access to nitrogen Beneficial microbes are overrepresented in the endogenous N source guild Diets that reduce availability of dietary N to microbes promote healthy aging Diet impact on host-microbiome interaction can be simplified for modeling