Emergence of plasmid-mediated colistin resistance and New Delhi metallo-β-lactamase genes in extensively drug-resistant Escherichia coli isolated from a patient in Thailand

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• 作者：Wantana Paveenkittiporn^a ; Anusak Kerdsin^b ; ^{noksak99@gmail.com} ; Sukanya Chokngam^c ; Charatdao Bunthi^d ; Somchai Sangkitporn^a ; Christopher J. Gregory^e
• 关键词：mcr-1 ; Colistin resistance ; XDR E.coli
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：87
• 期：2
• 页码：157-159
• 全文大小：169 K
• 卷排序：87

文摘

We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.