Combined effects of cadmium, temperature and hypoxia-reoxygenation on mitochondrial function in rainbow trout (Oncorhynchus mykiss)

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• 作者：John O. Onukwufor ; Don Stevens ; Collins Kamunde ; ^{ckamunde@upei.ca}
• 关键词：Cadmium ; Hypoxia-reoxygenation ; Temperature ; Mitochondrial bioenergetics ; Fish ; Reactive oxygen species ; Electron transport system
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：129-141
• 全文大小：4153 K
• 卷排序：182

文摘

Ternary interactions of Cd, temperature and H-R alter their individual and binary effects on mitochondrial bioenergetics. Oxidative stress explains many effects of Cd, H-R and temperature on mitochondria. Cd accumulation does not explain increased sensitivity of mitochondria to multiple stressors. Cd induces hormetic responses during H-R stress. Cd at low dose blunts conversion of complex I active (A)- to deactive (D)-form after H-R.