Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1

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• 作者：Zhi-Hai Wang^a ; ¹ ; Zhong Li^a ; ¹ ; Meng Hu^b ; ¹ ; Qing-Jie Yang^b ; Shen Yan^c ; Rong-Si Wu^c ; Bo-An Li^c ; ^{bali@xmu.edu.cn} ; Ming Guo^b ; ^{13358378777@163.com}
• 关键词：NSCLC ; non-small cell lung cancer ; ChIP ; chromatin immunoprecipitation ; EMT ; Epithelial-to-Mesenchymal Transition ; TMA ; tissue microarrays ; IRS ; immunoreactive score ; ORF ; open reading frame ; bHLH ; basic helix-loop-helix transcription factor
• 刊名：Gene
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：600
• 期：Complete
• 页码：1-8
• 全文大小：1475 K
• 卷排序：600

文摘

OVOL2 expression is correlated with the clinical stages of lung adenocarcinoma. Overexpression of OVOL2 represses EMT of lung adenocarcinoma. OVOL2 prevents the EMT by inhibition of Twist1 transcription directly.