Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
详细信息 查看全文
- 作者：Saoussen Ben Halima1 ; 2 ; 3 ; Sabyashachi Mishra4 ; 12 ; K. Muruga Poopathi Raja5 ; Michael Willem6 ; Antonio Baici4 ; Kai Simons7 ; Oliver Brü ; stle8 ; 9 ; 10 ; Philipp Koch8 ; Christian Haass6 ; 9 ; 11 ; Amedeo Caflisch4 ; Lawrence Rajendran1 ; 2 ; 3 ; rajendran@bli.uzh.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer disease ; APP ; BACE ; molecular dynamics ; subcellular compartmentalization ; membrane trafficking ; secretase ; amyloid ; Neuregulin
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：14
- 期：9
- 页码：2127-2141
- 全文大小：4271 K
文摘
- •
The AD-linked protease BACE1 cleaves APP to produce toxic β-amyloid peptides
- •
BACE1 also cleaves the non-amyloid substrates NRG1 and L1
- •
BACE1 cleavage of NRG1 and L1 is endocytosis-independent, unlike the cleavage of APP
- •
The endosomally targeted BACE1 inhibitor spares NRG1 and L1 but inhibits APP processing