Pharmacological characterization of intraplantar Complete Freund’s Adjuvant-induced burrowing deficits
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- 作者：Stacey Anne Gould ; Henri Doods ; Thorsten Lamla ; Anton Pekcec ; anton.pekcec@boehringer-ingelheim.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAALAC ; Association for Assessment and Accreditation of Laboratory Animal Care International ; ANOVA ; analysis of variance ; CFA ; Complete Freund&rsquo ; s adjuvant ; CHO DG44 ; Chinese hamster ovary- DG44 cells ; COX ; cyclooxygenase ; IASP ; International Association for the Study of Pain ; IgG ; immunoglobulin G ; IgG1 ; immunoglobulin G 1 ; i.p. ; intraperitoneal ; i.v. ; intravenous ; mAB ; monoclonal antibody ; NGF ; nerve growth factor ; NGFB ; nerve growth factor beta ; p.o. ; per os ; p75NTR ; p75 neurotrophin rec
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：301
- 期：Complete
- 页码：142-151
- 全文大小：1189 K
文摘
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Burrowing impairments after intraplantar CFA injection unmask spontaneous pain.
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Known analgesics (NSAIDs and an anti-NGF antibody) reinstate burrowing performance.
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Opioid efficacy is masked by sedative motor impairing side effects.
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Burrowing is not driven by an instinct to find shelter or biased by trait anxiety.
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Burrowing is an objective read-out for pain in the rat intraplantar CFA pain model.