Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents

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• 作者：Ceyda Acilan^a ; ^{ceyda.acilan@tubitak.gov.tr} ; Buse Cevatemre^b ; ¹ ; Zelal Adiguzel^a ; ¹ ; Didem Karakas^b ; Engin Ulukaya^c ; Ná ; dia Ribeiro^d ; Isabel Correia^d ; ^{icorreia@tecnico.ulisboa.pt} ; Joã ; o Costa Pessoa^d
• 关键词：Copper complexes ; Schiff base compounds ; Phenanthroline ; Interactions with DNA ; Anti-cancer drugs ; Mechanism of cytotoxicity of Cu-compounds
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：218-234
• 全文大小：3396 K
• 卷排序：1861

文摘

Three copper(II) complexes are synthesized and characterized. Cu(Sal-Gly)(pheamine) is the most specific complex towards cancer cells. The main mechanism of cell death is apoptosis. All complexes bind to DNA and induce oxidative damage. Harakiri is significantly upregulated in response to Cu(Sal-Gly)(pheamine).