Proteomic analysis of A2780/S ovarian cancer cell response to the cytotoxic organogold(III) compound Aubipyc
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- 作者：Tania Gamberia ; Lara Massaib ; Francesca Magherinia ; Ida Landinic ; Tania Fiaschia ; Federica Scalettib ; Chiara Gabbianid ; Laura Bianchie ; Luca Binie ; Stefania Nobilic ; Gabriele Perronec ; Enrico Minic ; Luigi Messorib ; luigi.messori@unifi.it" class="auth_mail ; Alessandra Modestia ; alessandra.modesti@unifi.it" class="auth_mail
- 关键词：Gold compounds ; Proteomics ; Two-dimensional electrophoresis ; Cancer
- 刊名：Journal of Proteomics
- 出版年：30 May 2014
- 年：2014
- 卷：103
- 期：Complete
- 页码：103-120
- 全文大小：1376 K
文摘
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Aubipyc is a promising gold(III) compound.
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Proteomic analysis of ovarian cancer cell line A2780/S response to Aubipyc treatment
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2-DE coupled to MS pointed out 87 differentially expressed protein spots.
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Most of these proteins belong to glucose metabolism, stress response.
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The functional analysis showed a negative effect of Aubipyc on energy metabolism.