A UPLC-MSMS method for the analysis of olanzapine in serum—with particular emphasis on drug stability testing
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- 作者：Trine Naalsund Andreassena ; trine.naalsund.andreassen@stolav.no" class="auth_mail" title="E-mail the corresponding author ; Berit Margrethe Hasle Falcha ; Olav Spigseta ; b
- 关键词：UPLC&ndash ; MSMS ; Olanzapine ; Serum ; Simple sample preparation ; Drug stability
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：1006
- 期：Complete
- 页码：112-120
- 全文大小：598 K
文摘
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A high throughput UPLC–MSMS method for olanzapine analysis in serum is presented.
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50,000–100,000 lux-h causes olanzapine degradation in patient samples.
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Patient samples are stable for least 7 h when exposed to daylight indoor.
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Relative olanzapine decrease seems to be independent of its original concentration.
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Light exposure causing degradation in spiked serum is lower than in patient serum.