Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis

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• 作者：Azliana Jusnida Ahmad Jafri^a ; Natasha Najwa Nor Arfuzir^a ; Lidawani Lambuk^a ; Igor Iezhitsa^a ; ^b ; ^{iezhitsa@yandex.ru} ; ^{Igor_Iezhitsa@yahoo.com} ; Renu Agarwal^a ; Puneet Agarwal^c ; Norhafiza Razali^a ; Anna Krasilnikova^a ; Maria Kharitonova^b ; ^d ; Vasily Demidov^e ; Evgeny Serebryansky^e ; Anatoly Skalny^e ; ^f ; ^g ; Alexander Spasov^b ; Ahmad Pauzi Md. Yusof^a ; Nafeeza Mohd Ismail^a
• 关键词：N-methyl-d-aspartate (NMDA) ; Excitotoxicity ; Retina ; Ganglion cell layer (GCL) ; Magnesium acetyltaurate (MgAT) ; Minerals ; Calcium (Ca) ; Magnesium (Mg) ; Potassium (K) ; Sodium (Na) ; Trace elements ; Iron (Fe) ; Zinc (Zn) ; Copper (Cu) ; Manganese (Mn) ; Selenium (Se) ; Inductively coupled plasma-mass spectrometry (ICP-MS)
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：147-154
• 全文大小：1942 K
• 卷排序：39

文摘

Intravitreal NMDA alters mineral and trace element concentration in rat retina. Intravitreal NMDA also increases retinal oxidative stress and causes retina damage. MgAT restores NMDA-induced changes in mineral and trace element concentration. MgAT also restores NMDA-induced changes in retinal redox status. Hence, MgAT provides protection against NMDA-induced retinal injury.