Comparative study of diclofenac-induced embryotoxicity and teratogenesis in Xenopus laevis and Lithobates catesbeianus, using the frog embryo teratogenesis assay: Xenopus (FETAX)
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- 作者：Jesú ; s Daniel Cardoso-Veraa ; Hariz Islas-Floresa ; hislasf@uaemex.mx" class="auth_mail" title="E-mail the corresponding author ; Nely SanJuan-Reyesa ; Elena Irabella Montero-Castroa ; Marcela Galar-Martí ; nezb ; Sandra Garcí ; a-Medinab ; Armando Elizalde-Velá ; zqueza ; Octavio Dublá ; n-Garcí ; aa ; Leobardo Manuel Gó ; mez-Olivá ; na ; lmgomezo@uaemex.mx" class="auth_mail" title="E-mail the corresponding author ; lgolivan74@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DCF ; diclofenac ; EC50 (malformation) ; effective concentration inducing 50% malformation ; FETAX ; frog embryo teratogenesis assay ; Xenopus ; LC50 ; median lethal concentration ; MBT ; mid-blastula transition ; NSAID ; nonsteroidal anti-inflammatory drugs ; ROS ; reactive oxygen species ; TI ; teratogenic index
- 刊名：Science of the Total Environment
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：574
- 期：Complete
- 页码：467-475
- 全文大小：1010 K
文摘
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L. catesbeianus is marketed as a nutritional meat source in Mexico
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Sensitivity to diclofenac exposure was compared in X. laevis and L. catesbeianus
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Diclofenac induced embryotoxicity and teratogenesis on L. catesbeianus and X. laevis
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Axial malformations, edema, and growth inhibition were induced in both species
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L. catesbeianus embryos are more sensitive to diclofenac exposure than X. laevis