Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats

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• 作者：Hong-Ying Yang¹ ; Wen-Meng Zhang¹ ; Wen-Wen Yang¹ ; Ting Zhao² ; Li-Xin Sun¹ ; ^{sunlixin67@yahoo.com}
• 关键词：16-dehydropregnenolone ; intramuscular administration ; pharmacokinetics ; high Performance liquid chromatography
• 刊名：Journal of Pharmaceutical Analysis
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：1
• 期：2
• 页码：135-138
• 全文大小：1107 K

文摘

The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a Single intramuscular administration (40 mg/kg). The concentration of 16-DHP in rat plasma was determined by a high Performance liquid chromatography (HPLC) method with UV detection. Levonorgestrel was used as the internal Standard (IS). The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a Single intramuscular administration, the maximum plasma concentration (C_max) was (289 ¡À 25) ng/mL, time to reach C_max(t_max) was (0.38 ¡À 0.14) h, the elimination half-life (t_1/2) was (2.5 ¡À 1.1) h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration (AUC_(0-t)) was (544 ¡À 73)ng ¡¤ h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection.