Effects of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites on DNA damage and repair under in vitro conditions
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- 作者：Eren Ozcaglia ; erenozcagli@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Buket Alpertungaa ; Concettina Fengab ; Mehmet Berktasc ; Christina Tsitsimpikoud ; Martin F. Wilkse ; Αristidis M. Tsatsakisf
- 关键词：3-MCPD ; Glycidol ; β-Chlorolactic acid ; Comet assay ; DNA damage ; DNA repair
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：1-7
- 全文大小：490 K
文摘
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3-MCPD/β-chlorolactic acid/glycidol induced DNA damage in NRK-52E and HEK-293 cells.
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H2O2 sensitivity increased with 3-MCPD, β-chlorolactic acid and glycidol treatments.
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DNA repair capacity in treated groups was not statistically different from controls.
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Higher purine base damage was determined in 20 μg/mL glycidol treated HEK-293 cells.