Synthesis and spectroscopic characterisation of novel bioactive molecule of 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives as effective anti-oxidant and anti-microbial agents

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• 作者：Chandravadivelu Gopi^a ; ^b ; Vedula Girija Sastry^c ; Magharla Dasaratha Dhanaraju^a ; ^{mddhanaraju@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chalcone ; Claisen&ndash ; Schmidt condensation ; DPPH assay ; Minimum inhibitory concentration (MIC) ; Zone of inhibition
• 刊名：Beni-Suef University Journal of Basic and Applied Sciences
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：5
• 期：3
• 页码：236-243
• 全文大小：905 K

文摘

The chief purpose of this work was to synthesise and find out the anti-oxidant and anti-microbial activities of novel 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives. These derivatives were prepared by performing Claisen–Schmidt condensation reaction of 1-(thiophen-2yl)ethanone and 2 substituted 1H-indole-3-carbaldehyde with constant stirring (approximately for 3 hours) in the presence of ethanol and potassium hydroxide. The newly synthesised compounds' anti-oxidant and anti-microbial activities have been identified by using DPPH radical scavenging assay, zone of inhibition and minimum inhibitory concentration. Most of the prepared compounds had shown excellent anti-oxidant and anti-microbial activities as compared to the standard drugs like Ascorbic acid, Ciprofloxacin and Fluconazole. Among the synthesised compounds, compounds 4e, 4h and 4a showed remarkable activity at low concentration. Therefore, these compounds deserve further research.