The excitability of tonic-firing SG neurons can be modulated by SK channels.
The two-way modulation of synapses by SK channels can be mimicked by high or low Ca2+ solutions.
The excitability increases of SK channels are mediated by Ca2+ influx.
Apamin-sensitive and -insensitive Ca2+-activated potassium channels modulate excitability by different pathways.
SK channels in the dorsal horn are potential targets for novel therapeutic analgesics.