Mebendazole crystal forms in tablet formulations. An ATR-FTIR/chemometrics approach to polymorph assignment
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- 作者：Natalia L. Calvo ; Teodoro S. Kaufman ; kaufman@iquir-conicet.gov.ar" class="auth_mail" title="E-mail the corresponding author ; Rubé ; n M. Maggio ; maggio@iquir-conicet.gov.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Crystal polymorphism ; Principal component analysis ; Mebendazole ; ATR-FTIR/chemometrics ; Form assignment
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：157-165
- 全文大小：2049 K
文摘
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ar0005">Polymorphs of mebendazole were differentiated by combining ATR-FTIR spectroscopy and PCA.
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ar0010">The mebendazole main form was assigned in differently treated commercial samples.
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ar0015">The procedure is simple, convenient and requires minimum sample pre-treatment.
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ar0020">Enabled fast, unambiguous confirmation of Form C as the main polymorph in tablets.
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ar0025">Non-destructive procedure; complies with principles of green analytical chemistry.