Cross-validation of clinical characteristics and treatment patterns associated with phenotypes for lithium response defined by the Alda scale

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• 作者：Jan Scott^a ; ^b ; ^{jan.scott@newcastle.ac.uk} ; Pierre Alexis Geoffroy^c ; ^d ; ^e ; ^f ; Sarah Sportiche^c ; ^d ; ^e ; Clara Brichant-Petit-Jean^c ; ^d ; ^e ; Sebastien Gard^e ; ^g ; Jean-Pierre Kahn^e ; ^h ; ⁱ ; Jean-Michel Azorin^e ; ^j ; ^k ; Chantal Henry^l ; ^m ; Bruno Etain^b ; ^c ; ^d ; ^e ; ^f ; Frank Bellivier^c ; ^d ; ^e ; ^f
• 关键词：Bipolar disorder ; Lithium ; Response ; Cross-validation ; Predictors ; Alda scale
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：62-67
• 全文大小：301 K
• 卷排序：208

文摘

This study examines simultaneously different methods of rating lithium response using the most widely used scale (the Alda Scale). Using continuous scores of lithium response or response categories leads to different predictors of response or non-response being identified. High B scale scores are associated with clinical features that are common in clinical populations such as the presence of alcohol or substance misuse or psychotic symptoms. This cross validation approach offers a useful methodology for exploring the utility of the Alda scale and other reliable measures of lithium response. A limitation of the findings is that rating scale is that it is primarily a retrospective measure of response.