Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

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• 作者：Aaron M. Swomley^a ; ^c ; ¹ ; Judy C. Triplett^a ; ^c ; ¹ ; Jeriel T. Keeney^a ; Govind Warrier^a ; Kevin J. Pearson^c ; ^d ; Julie A. Mattison^e ; Rafael de Cabo^e ; Jian Cai^b ; Jon B. Klein^b ; D. Allan Butterfield^a ; ^c ; ^{dabcns@uky.edu}
• 关键词：Resveratrol ; Proteomics ; Western diet ; Rhesus monkey ; Brain
• 刊名：The Journal of Nutritional Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：169-179
• 全文大小：1154 K
• 卷排序：39

文摘

A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.