Rhythmic Bdnf and TrkB expression patterns in the prefrontal cortex are lost in aged rats
详细信息 查看全文
- 作者：Cinthia D. Coria-Luceroa ; Rebeca S. Golinia ; Ivana T. Poncea ; Nicolas Deyurkaa ; Ana C. Anzulovicha ; Silvia M. Delgadoa ; b ; Lorena S. Navigatore-Fonzoa ; lnavigatore@unsl.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bdnf ; brain-derived neurothrophic factor ; CNS ; Central Nervous System ; CREB ; cAMP response element binding protein ; CT ; circadian times ; LTP ; long-term potentiation ; LTD ; long-term depression ; PFC ; Prefrontal cortex ; SCN ; suprachiasmatic nucleus ; TrkB ; tropomyosin related kinase B
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：1653
- 期：Complete
- 页码：51-58
- 全文大小：689 K
文摘
- •
Circadian rhythms of the clock’s BMAL1 protein and putative target genes are observed in the rat PFC.
- •
Creb1and TrkB expression display an endogenously-controlled 24 h variation.
- •
The expression levels of Bdnf exhibit ultradian rhythmicity in PFC rat.
- •
Aging abolishes Creb1, Bdnf and TrkB rhythms.
- •
Circadian rhythm of BMAL1 protein disappears in the PFC of aged rats.