New approaches for direct conversion of patient fibroblasts into neural cells
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- 作者：Suhasni Gopalakrishnan ; Pooja Hor ; Justin K. Ichida
- 关键词：Induced neuron ; Reprogramming ; Direct conversion ; Lineage conversion ; Disease modeling ; Neurological disease
- 刊名：Brain Research
- 出版年：2017
- 出版时间：1 February 2017
- 年：2017
- 卷：1656
- 期：Complete
- 页码：2-13
- 全文大小：936 K
- 卷排序：1656
文摘
●New neural cell types can be generated using direct conversion.●Direct conversion from pluripotent stem cells into neurons is highly efficient.●New approaches such as small molecules or miRNA replace transcription factors in neural reprogramming.●New studies show that induced neurons can model neurological disorders.●Future challenges in using direct conversion for translational studies.