TRAIL: a molecule with multiple receptors and control mechanisms

详细信息    查看全文

• 作者：Griffith ; Thomas S ; Lynch ; David H
• 关键词：DD death domain ; EST expressed sequence tag ; FADD Fas-associated DD protein ; FLICE FADD-like IL-1β ; -converting enzyme ; FLIP FLICE-like inhibitory protein ; TNF tumor necrosis factor ; TNF-R1 TNF receptor 1 ; TRADD TNF-R1-associated DD protein ; TRAIL TNF-
• 刊名：Current Opinion in Immunology
• 出版年：1998
• 出版时间：October, 1998
• 年：1998
• 卷：10
• 期：5
• 页码：559-563
• 全文大小：421 K

文摘

Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.