Synthesis, spectroscopic, thermal and anticancer studies of metal-antibiotic chelations: Ca(II), Fe(III), Pd(II) and Au(III) chloramphenicol complexes
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- 作者：Fatima A.I. Al-Khodira ; b ; Moamen S. Refatc ; d ; msrefat@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metal-antibiotic ; Chloramphenicol ; Vital metals ; Chelation ; Anticancer ; Nano-size
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：5 September 2016
- 年：2016
- 卷：1119
- 期：Complete
- 页码：157-166
- 全文大小：1403 K
文摘
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Ca(II), Fe(III), Pd(II) and Au(III) complexes of chloramphenicol drug have been synthesized and characterized.
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The Ca(II), Pd(II) and Au(III) metal ions coordinated to chloramphenicol through two hydroxyl groups with 1:1 or 1:2 ratios.
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Fe(III) ions chelated with chloramphenicol with 1:2 ratio via oxygen and nitrogen atoms of amido group.
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The iron(III) and gold(III) chloramphenicol complexes have nano-size particles.
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The cytotoxic activity of the gold(III) complex was tested against HCT-116 and HepG-2 tumor cell lines.