Gold nanorod embedded reduction responsive block copolymer micelle-triggered drug delivery combined with photothermal ablation for targeted cancer therapy

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• 作者：Sheetal Parida^a ; Chiranjit Maiti^b ; Y Rajesh^a ; Kaushik K Dey^a ; Ipsita Pal^a ; Aditya Parekh^a ; Rusha Patra^c ; Dibakar Dhara^b ; Pranab Kumar Dutta^c ; Mahitosh Mandal^a ; ^{mahitosh@smst.iitkgp.ernet.in}
• 关键词：TUNEL ; terminal deoxynucleotidyl transferase dUTP nick end labeling ; AIF ; apoptosis inducing factor ; IHC ; immunohistochemistry ; IgG ; immunoglobulin G ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5 diphenyltetrazolium bromide ; PI ; propidium iodide ; EDTA ; ethylenediaminetetraacetic acid ; PBS ; phosphate buffered saline ; GW ; GW627368X ; NanoGW ; nanoformulated GW627368X ; AuNR ; gold nanorod ; AuNR-BCPM ; gold nanorod embedded block copolymer micelle ; FA ; folic acid ; LA ; lipoic acid ; PEG ; polyethylene glycol ; NMR
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3039-3052
• 全文大小：3763 K
• 卷排序：1861

文摘

Reduction responsive diblock copolymer PEG-b-PHEA-LA-FA prepared by RAFT process AuNR Embedded Block Copolymer Micelle encapsulated highly hydrophobic GW627368X. AuNR-BCPM achieved targeted drug delivery and photothermal ablation simultaneously. Photothermal therapy induced cell death via necroptosis or programmed necrosis. Simultaneous PTT and GW627368X delivery enhanced therapeutic response.