Effects of intravenous bolus injection of nicorandil on renal artery flow velocity assessed by color Doppler ultrasound

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• 作者：Yukiko Shimamoto ; MD ; PhD^a ; Takashi Kubo ; MD ; PhD ; FJCC^b ; ^{takakubo@wakayama-med.ac.jp} ; Kazumi Tanabe ; PhD^a ; Hiroki Emori ; MD^b ; Yosuke Katayama ; MD^b ; Tsuyoshi Nishiguchi ; MD^b ; Akira Taruya ; MD^b ; Takeyoshi Kameyama ; MD ; PhD^b ; Makoto Orii ; MD ; PhD^b ; Takashi Yamano ; MD ; PhD^b ; Akio Kuroi ; MD ; PhD^b ; Tomoyuki Yamaguchi ; MD^b ; Kazushi Takemoto ; PhD^b ; Yoshiki Matsuo ; MD ; PhD^b ; Yasushi Ino ; MD ; PhD^b ; Atsushi Tanaka ; MD ; PhD^b ; Takeshi Hozumi ; MD ; PhD^b ; Masaki Terada ; MD ; PhD^a ; Takashi Akasaka ; MD ; PhD ; FJCC^b
• 关键词：Nicorandil ; Adenosine triphosphate-sensitive potassium channel ; Renal artery ; Color Doppler ultrasound
• 刊名：Journal of Cardiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：69
• 期：1
• 页码：364-368
• 全文大小：1064 K
• 卷排序：69

文摘

Previous animal studies have shown that a potassium channel opener, nicorandil, provokes vasodilation in renal microvasculature and increases renal blood flow. We conducted a clinical study that aimed to evaluate the effect of nicorandil on renal artery blood flow in comparison with nitroglycerin by using color Doppler ultrasound.MethodsThe present study enrolled 40 patients with stable coronary artery disease who had no renal arterial stenosis and renal parenchymal disease. The patients received intravenous administration of nicorandil (n = 20) or nitroglycerin (n = 20). Before and after the administration, renal artery blood flow velocity was measured by color-guided pulsed-wave Doppler.ResultsThe peak-systolic, end-diastolic, and mean renal artery blood flow velocities before the administration were not different between the nicorandil group and the nitroglycerin group. The peak-systolic (79 ± 15 cm/s to 99 ± 21 cm/s, p < 0.001; and 78 ± 19 cm/s to 85 ± 19 cm/s, p = 0.004), end-diastolic (22 ± 5 cm/s to 28 ± 8 cm/s, p < 0.001; and 24 ± 6 cm/s to 26 ± 6 cm/s, p = 0.005) and mean (41 ± 6 cm/s to 49 ± 9 cm/s, p < 0.001; and 43 ± 9 cm/s to 45 ± 9 cm/s, p = 0.009) renal artery flow velocities increased significantly in either group. The nominal changes in the peak-systolic (20 ± 10 cm/s vs. 7 ± 8 cm/s, p < 0.001), end-diastolic (5 ± 4 cm/s vs. 2 ± 3 cm/s, p = 0.001), and mean (8 ± 5 cm/s vs. 2 ± 2 cm/s, p < 0.001) renal artery blood flow velocities were significantly greater in the nicorandil group compared with the nitroglycerin group.ConclusionIntravenous nicorandil increased renal artery blood flow velocity in comparison with nitroglycerin. Nicorandil has a significant effect on renal hemodynamics.