Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis
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- 作者：Eva Inigueza ; Armando Varela-Ramireza ; Alberto Martí ; nezb ; amartinez@CityTech.Cuny.Edu" class="auth_mail" title="E-mail the corresponding author ; Caresse L. Torresa ; Roberto A. Sá ; nchez-Delgadoc ; Rosa A. Maldonadoa ; ramaldonado@utep.edu" class="auth_mail" title="E-mail the corresponding author ; ramalmed@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Cutaneous leishmaniasis ; Drug discovery ; Leishmania major ; Parasites ; Ruthenium-clotrimazole complex
- 刊名：Acta Tropica
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：402-410
- 全文大小：1762 K
文摘
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Metal compounds and its synergistic activity against cutaneous leishmaniasis.
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Ru-CTZ compounds exert a mitochondrial dependent apoptotic-like death in L. major promastigotes.
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Therapeutic efficacy in vivo of AM162 in the mouse model of cutaneous leishmaniasis.
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A new candidate to compose AM162-derived analogs and new chemical formulations.