A novel method for nucleos(t)ide analogues susceptibility assay of hepatitis B virus by viral polymerase transcomplementation
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- 作者：Ying-ying Luoa ; 1 ; Ying Taoa ; b ; 1 ; Xue-fei Caia ; Wen-lu Zhanga ; Quan-xin Longa ; Haitao Guoc ; Ai-long Huanga ; d ; ahuang1964@163.com" class="auth_mail" title="E-mail the corresponding author ; Jie-li Hua ; d ; hujieli1977@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis B virus ; Susceptibility assay
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：99-107
- 全文大小：1035 K
文摘
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An acceptor cell line stably transfected with a polymerase-null HBV 1.1mer genome DNA was established.
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Stable cell lines replicating HBV DNA with the trans-complemented HBV polymerases were established.
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This strategy shortens the time needed for HBV replicating stable cell establishment to 3–4 weeks.