Intraoperative remifentanil has been clinically associated with opioid-induced hyperalgesia.
We prospectively collected observational data in patients undergoing thyroidectomy.
We studied effects of intraoperative remifentanil on postoperative pain management.
We analyzed 5 primary and 5 secondary outcomes from an anonymous questionnaire.
Remifentanil was significantly associated with worse patient-reported outcomes.