Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway
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- 作者：Feng-Tao Liua ; b ; 1 ; liuft110@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Yu-Jie Yanga ; b ; c ; 1 ; yujieyang1015@me.com" class="auth_mail" title="E-mail the corresponding author ; Jian-Jun Wua ; b ; jungliw@126.com" class="auth_mail" title="E-mail the corresponding author ; Shan Lic ; shanli1121@163.com" class="auth_mail" title="E-mail the corresponding author ; Yi-Lin Tanga ; b ; tangyilin10@163.com" class="auth_mail" title="E-mail the corresponding author ; Jue Zhaoa ; b ; orangerange_zj@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Zhen-Yang Liua ; b ; besuretowin@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bao-Guo Xiaoa ; b ; bgxiao@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ji Zuoc ; jzuo@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wen Liuc ; liuwen@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jian Wanga ; b ; wangjian336@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-syn ; α-synuclein ; PD ; Parkinson׳s disease ; ROCK ; Rho kinase ; WT ; wild-type ; LBs ; Lewy bodies ; UPS ; ubiquitin proteasome system ; BSA ; bovine serum albumin ; CMA ; chaperone-mediated autophagy ; 3-MA ; 3-methyladenine ; Co-IP ; Co-Immunoprecipitation ; TEM ; Transmission Electron Microscope ; PI3K ; phosphoinositide 3-kinase ; JNK 1 ; c-Jun N-terminal kinase 1.
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：1632
- 期：Complete
- 页码：9-18
- 全文大小：3111 K
文摘
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A53T α-synuclein could decrease neurite outgrowth with enhanced Rho kinase activity.
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Fasudil could attenuate the neurite outgrowth injury caused by A53T α-synuclein.
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Fasudil could promote the autophagic degradation of A53T α-synuclein.
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The effect of fasudil was mediated by JNK/Bcl-2/beclin 1/Vps34 pathway.