Second Cancer Risk and Late Mortality in Adult Australians Receiving Allogeneic Hematopoietic Stem Cell Transplantation: A Population-Based Cohort Study
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- 作者：Claire M. Vajdic1 ; claire.vajdic@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; Eleni Mayson2 ; Anthony J. Dodds2 ; Tracey O'Brien3 ; Leonie Wilcox4 ; Ian Nivison-Smith4 ; Renate Le Marsney1 ; Benjamin Daniels1 ; Lesley J. Ashton5 ; on behalf of the CAST study investigatorsL. Ashton ; R. Le Marsney ; A. Dodds ; J. Tan ; I. Bilmon ; L. Wilcox ; I. Nivison-Smith ; D. Aarons ; S. Tran ; C. Vajdic ; J. Gibson ; A. Johnston ; M. Greenwood ; M. Forbes ; M. Hertzberg ; G. Huang ; A. Spencer ; J. Muirhead ; J. Szer ; K. Mason ; I. Lewis ; C. To ; S. Durrant ; R. Western ; P. Cannell ; S. Buffery ; T. O'Brien ; C. Oswald ; A. Nelson ; P. Shaw ; L. Pearson ; K. Tiedemann ; M. Scoyne ; C. Fraser ; J. Seljak ; C. Cole ; K. Rowland ; H. Gough ; H. Tapp ; N. Green
- 关键词：Allogeneic transplantation ; Malignancy ; Mortality ; Risk ; Surveillance ; Prevention
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：22
- 期：5
- 页码：949-956
- 全文大小：329 K
文摘
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We examined cancer and late death after adult allogeneic HSCT in Australia.
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The cumulative incidence of second cancer at 10 years was 3.35%.
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They key determinant of second cancer risk was cGVHD.
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The relative risk of late death (standardized mortality ratio) was 14-fold that of the general population.
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Relapse and cGVHD were strongly related to late death.