Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function
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- 作者：Yevgeniya O. Lukyanenkoa ; 1 ; Lukyanenkoy@nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Antoine Younesa ; 1 ; Younesa@nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Alexey E. Lyashkova ; b ; 1 ; Alexey.lyashkov@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Kirill V. Tarasova ; 1 ; Tarasovkv@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Daniel R. Riordona ; RiordonD@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Joonho Leea ; Joon.lee@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Syevda G. Sirenkoa ; Sirenkos@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Evgeny Kobrinskya ; KobrinskiEv@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Bruce Zimana ; ZimanB@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Yelena S. Tarasovaa ; Tarasovay@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Magdalena Juhaszovaa ; Juhaszovam@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Steven J. Sollotta ; SollottS@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; David R. Grahamb ; Dgraham@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Edward G. Lakattaa ; lakattae@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heart ; Sinoatrial node pacemaker cells ; Phosphodiesterase Type 1A ; Calcium ; cAMP
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：73-82
- 全文大小：1563 K
文摘
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PDE1A expression and activity are higher in sinoatrial node than in left ventricle.
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PDE1A immunolabeling is localized close to the cell surface membrane of SANC.
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PDE1A cAMP regulation modulates basal SANC pacemaker function.