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Sleep complaints are associated with reduced left prefrontal activation during a verbal fluency task in patients with major depression: A multi-channel near-infrared spectroscopy study
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NIRS is used to assist with the differential diagnosis of MDD.

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It is unclear whether NIRS signals are altered by sleep disturbance in MDD.

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PSQI was associated with decreased reactivity of the left prefrontal region.

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Actigraphic variables prior to the NIRS showed no significant correlation.

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Sleep complaints should be considered for clinical application of NIRS.

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