Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells
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- 作者：Dahong Yaoa ; 1 ; Jing Wangb ; 1 ; Guan Wanga ; 1 ; Yingnan Jianga ; Lei Shangc ; Yuqian Zhaoa ; Jian Huanga ; Shilin Yanga ; yangshilin@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jinhui Wanga ; profwjh@126.com" class="auth_mail" title="E-mail the corresponding author ; Yamei Yud ; yuyamei252000@163.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：112-123
- 全文大小：2260 K
文摘
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A novel series of coumarin derivatives were designed, synthesized.
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These compounds containing piperazine had significant inhibition activities on AChE.
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class="boldFont">9x could induce cytoprotective autophagy to attenuate H2O2-induced cell death.
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Discovery of a new compound class="boldFont">9x targeting AChE with autophagy-inducing activity.
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