Development of a selective and fast LC-MS/MS for determination of WSJ-537, an xanthine oxidase inhibitor, in rat plasma: Application to a pharmacokinetic study
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- 作者：Jianyang Lin ; linjianyangydyy@126.com" class="auth_mail" title="E-mail the corresponding author ; Tian Yang ; Donghu Zhang
- 关键词：WSJ-537 ; Pharmacokinetics ; LC&ndash ; MS/MS ; Rats
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：1028
- 期：Complete
- 页码：51-55
- 全文大小：738 K
文摘
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An LC–MS/MS method for determinaton of WSJ-537 in rat plasma was developed.
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An LLOQ of 20 ng/mL was achieved.
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The pharmacokinetics of WSJ-537 in rats was conducted for the first time.