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The viral non-structural protein 1 alpha (Nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells
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The Nsp1α of PRRSV was a negative regulator of p53 activity through increasing mdm2 expression and p53 ubiquitination.

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The p53 appears to be inhibitory to PRRSV replication at early infection.

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