Brain-derived neurotrophic factor promotes vesicular glutamate transporter 3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5
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- 作者：Dong Liua ; cyyzld@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhen Liua ; zhen@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Huaxiang Liub ; huaxiangliu@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Hao Lic ; lihao462929@163.com" class="auth_mail" title="E-mail the corresponding author ; Xinliang Pand ; 13606371129@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhenzhong Lia ; zli@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Brain-derived neurotrophic factor ; Vesicular glutamate transporter 3 ; Etv4 ; Etv5 ; Neurite outgrowth ; Dorsal root ganglion
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：215-226
- 全文大小：3073 K
文摘
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BDNF promoted Etv4 and Etv5 and their mRNA expression in DRG neurons.
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Inhibition of ERK1/2 blocked the effects of BDNF on Etv4 and Etv5 expression.
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siRNA of Etv4 and Etv5 blocked BNDF induced VGLUT3 expression and neurite growth.
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Overexpression of Etv4 or Etv5 potentiated BNDF induced neurite elongation.
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Etv4 or Etv5 is essential transcription factor for BDNF mediating VGLUT3 expression.