Proinflammatory T cells and IL-17 stimulate osteoblast differentiation
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- 作者：Michiel Croesa ; m.croes@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; F. Cumhur Ö ; nera ; f.c.oner@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; Danihel van Neervena ; dvanneerven87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ekrem Sabira ; ekrem_sabir1990@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Moyo C. Kruyta ; m.c.kruyt@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; Taco J. Blokhuisb ; t.j.blokhuis@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; Wouter J.A. Dherta ; c ; w.dhert@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Jacqueline Alblasa ; j.alblas@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoimmunology ; Fracture healing ; Bone regeneration ; Mesenchymal stem cell ; T lymphocytes
- 刊名：Bone
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：262-270
- 全文大小：1095 K
文摘
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Activated T cells produce soluble factors that contribute to the osteoblast differentiation of human mesenchymal stem cells.
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The cytokines produced by proinflammatory T helper 17 cells potently synergize with BMP-2 to induce osteogenesis.
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We propose that distinct T cell subsets and their secreted factors may differently affect the outcome of bone regeneration.